Regulatory T cells: immune suppression and beyond

被引：71

作者：

Wan, Yisong Y. ^{[1
]}

机构：

[1] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2010年 / 7卷 / 03期

关键词：

Foxp3; Treg; immunosuppression and plasticity; FOLLICULAR-HELPER-CELLS; GROWTH-FACTOR-BETA; GENETICALLY SUSCEPTIBLE MICE; IMMUNOLOGICAL SELF-TOLERANCE; INTERFERON-GAMMA PRODUCTION; TRANSCRIPTION FACTOR FOXP3; COLONY-STIMULATING FACTOR; MESSENGER-RNA EXPRESSION; TGF-BETA; IN-VIVO;

D O I：

10.1038/cmi.2010.20

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Foxp3-expressing regulatory T cells (Tregs) were originally identified as critical in maintaining self-tolerance and immune homeostasis. The immunosuppressive functions of Tregs are widely acknowledged and have been extensively studied. Recent studies have revealed many diverse roles of Tregs in shaping the immune system and the inflammatory response. This review will discuss our efforts as well as the efforts of others towards understanding the multifaceted function of Tregs in immune regulation. Cellular & Molecular Immunology (2010) 7, 204-210; doi:10.1038/cmi.2010.20; published online 12 April 2010

引用

页码：204 / 210

页数：7

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