The (epi)genetic control of mammalian X-chromosome inactivation

被引:66
作者
Lee, JT [1 ]
Jaenisch, R [1 ]
机构
[1] MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114
关键词
D O I
10.1016/S0959-437X(97)80138-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In mammals, the X chromosome is uniquely capable of complete inactivation. Research in the past two years has validated the long-held hypothesis that the 'X-inactivation center' (Xic) controls events of X inactivation and that its resident gene Xist is not only required but is at least partially responsible for the cis-restriction of X inactivation. Progress has also been made in identifying genes within the Xic. Although Xist remains the only known required element, evidence now suggests that a separate element for X counting must exist and that the Xic may be entirely contained within a 450 kb sequence. This small region may be sufficient for both initiation and establishment of X inactivation.
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收藏
页码:274 / 280
页数:7
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