Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States - Data from the Third National Health and Nutrition Examination Survey

被引:645
作者
Martins, David
Wolf, Myles
Pan, Deyu
Zadshir, Ashraf
Tareen, Naureen
Thadhani, Ravi
Felsenfeld, Arnold
Levine, Barton
Mehrotra, Rajnish
Norris, Keith
机构
[1] Charles R Drew Univ Med & Sci, Dept Med, Lynwood, CA 90262 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA
[3] Harvard Univ, Sch Med, Dept Med, Boston, MA USA
[4] VA Greater LA Healthcare Syst, Dept Med, Los Angeles, CA USA
[5] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA
关键词
D O I
10.1001/archinte.167.11.1159
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Results of several epidemiologic and clinical studies have suggested that there is an excess risk of hypertension and diabetes mellitus in persons with suboptimal intake of vitamin D. Methods: We examined the association between serum levels of 25-hydroxyvitamin D ( 25[ OH] D) and select cardiovascular disease risk factors in US adults. A secondary analysis was performed with data from the Third National Health and Nutrition Examination Survey, a national probability survey conducted by the National Center for Health Statistics between January 1, 1988, and December 31, 1994, with oversampling of persons 60 years and older, non-Hispanic black individuals, and Mexican American individuals. Results: There were 7186 male and 7902 female adults 20 years and older with available data in the Third National Health and Nutrition Examination Survey. The mean 25( OH) D level in the overall sample was 30 ng/mL ( 75 nmol/L). The 25( OH) D levels were lower in women, elderly persons ( >= 60 years), racial/ethnic minorities, and participants with obesity, hypertension, and diabetes mellitus. The adjusted prevalence of hypertension ( odds ratio [ OR], 1.30), diabetes mellitus ( OR, 1.98), obesity ( OR, 2.29), and high serum triglyceride levels ( OR, 1.47) was significantly higher in the first than in the fourth quartile of serum 25( OH) D levels ( P < .001 for all). Conclusions: Serum 25( OH) D levels are associated with important cardiovascular disease risk factors in US adults. Prospective studies to assess a direct benefit of cholecalciferol ( vitamin D) supplementation on cardiovascular disease risk factors are warranted.
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页码:1159 / 1165
页数:7
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