Toxic neuropathy in patients with pre-existing neuropathy

被引：125

作者：

Chaudhry, V

Chaudhry, M

Crawford, TO

Simmons-O'Brien, E

Griffin, JW

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA

[3] Greater Baltimore Med Ctr, Dept Oncol, Baltimore, MD USA

来源：

NEUROLOGY | 2003年 / 60卷 / 02期

关键词：

D O I：

10.1212/01.WNL.0000043691.53710.53

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report significant worsening of a pre-existing neuropathy in six patients who received "non-toxic" dosages of known neurotoxic agents. Before treatment, baseline total neuropathy score (TNS) averaged 9.5 (range 0 to 19). After chemotherapy (Taxol [125 to 175 mg/m(2) X 4]; vincristine [2 to 5 mg]; cisplatin [40 mg/m(2) x 8]; and thalidomide [60 g]), the TNS averaged 22 (range 13 to 29). The authors conclude that functionally disabling toxic neuropathy can occur in patients with pre-existing neuropathy at standard doses.

引用

收藏

页码：337 / 340

页数：4

相关论文

共 10 条

[1]

Thalidomide: Current and potential clinical applications [J].

Calabrese, L ;

Fleischer, AB .

AMERICAN JOURNAL OF MEDICINE, 2000, 108 (06) :487-495

[2]

VINCRISTINE NEUROPATHY - CLINICAL AND ELECTROPHYSIOLOGICAL OBSERVATIONS [J].

CASEY, EB ;

JELLIFE, AM ;

LEQUESNE, PM ;

MILLETT, YL .

BRAIN, 1973, 96 :69-86

[3]

PERIPHERAL NEUROPATHY FROM TAXOL AND CISPLATIN COMBINATION CHEMOTHERAPY - CLINICAL AND ELECTROPHYSIOLOGICAL STUDIES [J].

CHAUDHRY, V ;

ROWINSKY, EK ;

SARTORIUS, SE ;

DONEHOWER, RC ;

CORNBLATH, DR .

ANNALS OF NEUROLOGY, 1994, 35 (03) :304-311

[4]

CHAUDHRY V, IN PRESS NEUROLOGY

[5]

Total neuropathy score - Validation and reliability study [J].

Cornblath, DR ;

Chaudhry, V ;

Carter, K ;

Lee, D ;

Seysedadr, M ;

Miernicki, M ;

Joh, T .

NEUROLOGY, 1999, 53 (08) :1660-1664

[6]

Acute deterioration of Charcot-Marie-Tooth disease IA (CMT IA) following 2 mg of vincristine chemotherapy [J].

Hildebrandt, G ;

Holler, E ;

Woenkhaus, M ;

Quarch, G ;

Reichle, A ;

Schalke, B ;

Andreesen, R .

ANNALS OF ONCOLOGY, 2000, 11 (06) :743-747

[7]

Hilkens P H, 1997, J Peripher Nerv Syst, V2, P350

[8]

VINCRISTINE NEUROPATHY IN TYPE-I AND TYPE-II CHARCOT-MARIE-TOOTH DISEASE (HEREDITARY MOTOR SENSORY NEUROPATHY) [J].

IGARASHI, M ;

THOMPSON, EI ;

RIVERA, GK .

MEDICAL AND PEDIATRIC ONCOLOGY, 1995, 25 (02) :113-116

[9]

Chemotherapy-induced peripheral neuropathy [J].

Quasthoff, S ;

Hartung, HP .

JOURNAL OF NEUROLOGY, 2002, 249 (01) :9-17

[10]

DEVELOPMENT OF POLYNEUROPATHY DURING THALIDOMIDE THERAPY [J].

WULFF, CH ;

HOYER, H ;

ASBOEHANSEN, G ;

BRODTHAGEN, H .

BRITISH JOURNAL OF DERMATOLOGY, 1985, 112 (04) :475-480