Synthesis of polyfunctional indoles and related heterocycles mediated by cesium and potassium bases

被引：259

作者：

Koradin, C ^{[1
]}

Dohle, W ^{[1
]}

Rodriguez, AL ^{[1
]}

Schmid, B ^{[1
]}

Knochel, P ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

TETRAHEDRON | 2003年 / 59卷 / 09期

关键词：

indoles; heterocycles; cesium and potassium bases; cyclization;

D O I：

10.1016/S0040-4020(03)00073-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general preparation of 2-substituted indoles starting from functionalized 2-alkynylanilines has been developed. This base mediated reaction has also been used to synthesize the heterocyclic core of the marine alkaloid hinckdentine A. Furthermore the reaction was successfully adapted to the solid phase. Benzofurans and isoindolones could also be prepared with this method. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1571 / 1587

页数：17

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