Imipenem resistance in a Salmonella clinical strain due to plasmid-mediated class a carbapenemase KPC-2

被引：156

作者：

Miriagou, V

Tzouvelekis, LS

Rossiter, S

Tzelepi, E

Angulo, FJ

Whichard, JA

机构：

[1] Ctr Dis Control & Prevent, Foodborne & Diarrheal Dis Branch, Div Bacterial & Mycot Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA

[2] Univ Athens, Sch Med, Dept Microbiol, GR-11527 Athens, Greece

[3] Univ Athens, Hellen Pasteur Inst, Bacteriol Lab, Athens, Greece

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 04期

关键词：

D O I：

10.1128/AAC.47.4.1297-1300.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A Salmonella enterica serotype Cubana isolate exhibiting resistance to most beta-lactam antibiotics, including oxyimino-cephalosporins and imipenem, was isolated from a 4-year-old boy with gastroenteritis in Maryland. beta-Lactam resistance was mediated by a conjugative plasmid that encoded KPC-2, a class A carbapenemase previously found in a Klebsiella pneumoniae isolate from the Maryland area as well. Sequence analysis of the flanking regions indicated a potential association of bla(KPC-2) with mobile structures.

引用

页码：1297 / 1300

页数：4

共 25 条

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