Bioreduction of fluoroacetophenones by the fungi Aspergillus terreus and Rhizopus oryzae

被引:36
作者
Comasseto, JV [1 ]
Omori, AT [1 ]
Andrade, LH [1 ]
Porto, ALM [1 ]
机构
[1] Univ Sao Paulo, Inst Quim, BR-05508900 Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
D O I
10.1016/S0957-4166(03)00096-X
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The enantioselective bioreduction of a number of fluoroacetophenones was carried out with whole cells of Rhizopus oryzae CCT 4964, Aspergillits terreus CCT 3320 and Aspergillus terreus CCT 4083 giving the corresponding alcohols in good yield and high enantioselectivity. Initial results with these fungi indicated that some of them are promising biocatalysts for deracemization reactions of secondary alcohols. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:711 / 715
页数:5
相关论文
共 25 条
[1]   Microbial deracemization of 1-aryl and 1-heteroaryl secondary alcohols [J].
Allan, GR ;
Carnell, AJ .
JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (19) :6495-6497
[2]   First evaluation of the Brazilian microorganisms biocatalytic potential [J].
Cagnon, JR ;
Porto, ALM ;
Marsaioli, AJ ;
Manfio, GP ;
Eguchi, SY .
CHEMOSPHERE, 1999, 38 (10) :2237-2242
[3]   Asymmetric bioreductions: application to the synthesis of pharmaceuticals [J].
Chartrain, M ;
Greasham, R ;
Moore, J ;
Reider, P ;
Robinson, D ;
Buckland, B .
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2001, 11 (4-6) :503-512
[4]   Biocatalysis and enzymes in organic synthesis [J].
Davis, BG ;
Borer, V .
NATURAL PRODUCT REPORTS, 2001, 18 (06) :618-640
[5]   Fungal deracemization of benzoin [J].
Demir, AS ;
Hamamci, H ;
Sesenoglu, O ;
Neslihanoglu, R ;
Asikoglu, B ;
Capanoglu, D .
TETRAHEDRON LETTERS, 2002, 43 (36) :6447-6449
[6]  
Faber K., 2000, Biotransformations in Organic Chemistry, V4th
[7]   Effect of additives on the bioreduction of 2-chloro-1-phenyl-2-propen-1-one by baker's yeast [J].
Filho, EPS ;
Rodrigues, JAR ;
Moran, PJS .
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2001, 15 (1-3) :23-28
[8]   Asymmetric reduction of ketones via whole cell bioconversions and transfer hydrogenation: complementary approaches [J].
Hage, A ;
Petra, DGI ;
Field, JA ;
Schipper, D ;
Wijnberg, JBPA ;
Kamer, PCJ ;
Reek, JNH ;
van Leeuwen, PWNM ;
Wever, R ;
Schoemaker, HE .
TETRAHEDRON-ASYMMETRY, 2001, 12 (07) :1025-1034
[9]  
Halgas, 1992, BIOCATALYSTS ORGANIC
[10]   Efficient resolution of prostereogenic arylaliphatic ketones using a recombinant alcohol dehydrogenase from Pseudomonas fluorescens [J].
Hildebrandt, P ;
Riermeier, T ;
Altenbuchner, J ;
Bornscheuer, UT .
TETRAHEDRON-ASYMMETRY, 2001, 12 (08) :1207-1210