Destruction of human blood cells in interaction with detonation nanodiamonds in experiments in vitro

被引：36

作者：

Puzyr, AP

Neshumayev, DA

Tarskikh, SV

Makarskaya, GV

Dolmatov, VY ^{[1
]}

Bondar, VS

机构：

[1] Russian Acad Sci, Siberian Branch, Inst Biophys, Krasnoyarsk, Russia

[2] Russian Acad Sci, Siberian Branch, Dept Immunol, KSC, Krasnoyarsk, Russia

[3] JSC, Diamond Ctr, Sci Prod Dept, St Petersburg 192076, Russia

来源：

关键词：

nanodiamonds; white blood cells; erythrocytes; chemiluniscence;

D O I：

10.1016/j.diamond.2004.06.003

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In experiments in vitro on human blood, it was shown that nanodianiond (ND) particles change the kinetics of active oxygen generation (AOG), causing white cell destruction and erythrocyte hemolysis. Various mechanisms of the observed effects have been considered. Nanodianionds adapted for biological research and possessing higher colloidal stability make it possible to obtain sterile hydrosols and mixtures with drugs and are more preferable for medical -biological research. We discussed the necessity of experiments in vivo and showed the first results of injection of the adapted nanodianionds to the laboratory animals. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：2020 / 2023

页数：4