Do endogenous ligands of peripheral μ- and δ-opiate receptors mediate antiarrhythmic and cardioprotective effects of Rhodiola rosea?

被引：6

作者：

Maslov, LN ^{[1
]}

Lishmanov, YB ^{[1
]}

Naumova, AV ^{[1
]}

Lasukova, TV ^{[1
]}

机构：

[1] Russian Acad Med Sci, Siberian Div, Inst Cardiol, Dept Expt Cardiol, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1997年 / 124卷 / 08期

关键词：

mu- and delta-opiate receptors; arrhythmias; isolated heart; adaptogens;

D O I：

10.1007/BF02445082

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Oral administration of Rhodiola rosea extract to rats (3.5 ml/kg, 8 days) prevents reperfusion arrhythmias and elicits a protective effect in experiments on isolated heart. Experiments with naloxone and ICI 174,864 suggest-that the antiarrhythmic effect of R. rosea extract is mediated through activation of mu-opiate receptors in the myocardium. The cardioprotective effect of this extract is not associated with opiate receptors.

引用

页码：754 / 756

页数：3

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