The bronchodilator response to salmeterol is maintained with regular, long-term use in patients with COPD

Long-acting beta(2)-agonists (LABAs) are recommended in the management of patients with chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated that the LABA, salmeterol, improves lung function, symptoms and quality of life. in patients with COPD. In this study, we have performed additional analyses of the combined data from two previous double-blind, placebo-controlled. parallel studies of salmeterol (50 mug b.i.d) in patients with COPD. The new analyses reveal that the significant improvements seen in pre-dose and 2-h post-dose forced expiratory volume in 1 s (FEV1) compared to placebo, occur early in the treatment period, and are sustained for at least 24 weeks. Moreover, improvements in peak expiratory flow rate occur as early as Day 1. and are sustained throughout the 24-week period. Additional analyses of 12-h FEV1 data also show that salmeterol is associated with an increase in the area under the curve at Week 12 compared with Day 1, adding further support to evidence that it results in a sustained bronchodilator response. with no evidence of tolerance. (C) 2004 Elsevier Ltd. All rights reserved.