Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives

被引：64

作者：

Lien, JC

Huang, LJ

Wang, JP

Teng, CM

Lee, KH

Kuo, SC ^{[1
]}

机构：

[1] China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan

[2] Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan

[3] Natl Taiwan Univ, Coll Med, Pharmacol Inst, Taipei, Taiwan

[4] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1997年 / 5卷 / 12期

关键词：

D O I：

10.1016/S0968-0896(97)00133-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 2-substituted 3-chloro-1,4-naphthoquinones was synthesized, and the antiplatelet, antiinflammatory, and antiallergic activities of these compounds were evaluated. The structure-activity relationships in this series were also examined. Most of the 2-alkyl/arylcarboxamido derivatives of 3-chloro-1,4-naphthoquinone showed potent activities with similar trends in each of the activities evaluated. (C) 1997 Elsevier Science Ltd.

引用

页码：2111 / 2120

页数：10

共 10 条

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