The effect of the phenolic antioxidant ferulic acid on the oxidation of low density lipoprotein depends on the pro-oxidant used

被引：36

作者：

Bourne, LC ^{[1
]}

RiceEvans, CA ^{[1
]}

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,INT ANTIOXIDANT RES CTR,LONDON SE1 9RT,ENGLAND

来源：

FREE RADICAL RESEARCH | 1997年 / 27卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ferulic acid; oxidized low density lipoprotein; copper; metmyoglobin;

D O I：

10.3109/10715769709065771

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The action of ferulic acid during the oxidation of LDL has been investigated using both copper ions and the haem protein metmyoglobin as pro-oxidants. The results demonstrate the ability of ferulic acid to act as a pro-oxidant when LDL oxidation is induced by copper at concentrations of the phenolic acid which are protective when the LDL oxidation is mediated by metmyoglobin. The suggested mechanism involves the reduction of Cu2+ to Cu+ by ferulic acid resulting in the production of the ferulic phenoxyl radical.

引用

页码：337 / 344

页数：8

共 25 条

[1] TOCOPHEROL-MEDIATED PEROXIDATION - THE PROOXIDANT EFFECT OF VITAMIN-E ON THE RADICAL-INITIATED OXIDATION OF HUMAN LOW-DENSITY-LIPOPROTEIN [J].

BOWRY, VW ;

STOCKER, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (14) :6029-6044

[2] VITAMIN-E IN HUMAN LOW-DENSITY-LIPOPROTEIN - WHEN AND HOW THIS ANTIOXIDANT BECOMES A PROOXIDANT [J].

BOWRY, VW ;

INGOLD, KU ;

STOCKER, R .

BIOCHEMICAL JOURNAL, 1992, 288 :341-344

[3] ANTIOXIDANT POTENTIAL OF INTERMEDIATES IN PHENYLPROPANOID METABOLISM IN HIGHER-PLANTS [J].

CASTELLUCCIO, C ;

PAGANGA, G ;

MELIKIAN, N ;

BOLWELL, GP ;

PRIDHAM, J ;

SAMPSON, J ;

RICEEVANS, C .

FEBS LETTERS, 1995, 368 (01) :188-192

[4] Differential distribution of ferulic acid to the major plasma constituents in relation to its potential as an antioxidant [J].

Castelluccio, C ;

Bolwell, GP ;

Gerrish, C ;

RiceEvans, C .

BIOCHEMICAL JOURNAL, 1996, 316 :691-694

[5]

CHUNG BH, 1980, J LIPID RES, V21, P284

[6] THE ROLE OF LIPID-PEROXIDATION AND ANTIOXIDANTS IN OXIDATIVE MODIFICATION OF LDL [J].

ESTERBAUER, H ;

GEBICKI, J ;

PUHL, H ;

JURGENS, G .

FREE RADICAL BIOLOGY AND MEDICINE, 1992, 13 (04) :341-390

[7] ANTIOXIDANT POTENTIAL OF FERULIC ACID [J].

GRAF, E .

FREE RADICAL BIOLOGY AND MEDICINE, 1992, 13 (04) :435-448

[8] THE ROLE OF LIPID HYDROPEROXIDES IN THE MYOGLOBIN-DEPENDENT OXIDATION OF LDL [J].

HOGG, N ;

RICEEVANS, C ;

DARLEYUSMAR, V ;

WILSON, MT ;

PAGANGA, G ;

BOURNE, L .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1994, 314 (01) :39-44

[9] ALPHA-TOCOPHEROL MEDIATED PEROXIDATION IN THE COPPER(II) AND MET MYOGLOBIN INDUCED OXIDATION OF HUMAN LOW-DENSITY-LIPOPROTEIN - THE INFLUENCE OF LIPID HYDROPEROXIDES [J].

IWATSUKI, M ;

NIKI, E ;

STONE, D ;

DARLEYUSMAR, VM .

FEBS LETTERS, 1995, 360 (03) :271-276

[10] alpha-Tocopherol as a reductant for Cu(II) in human lipoproteins - Triggering role in the initiation of lipoprotein oxidation [J].

Kontush, A ;

Meyer, S ;

Finckh, B ;

Kohlschutter, A ;

Beisiegel, U .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (19) :11106-11112

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