Novel synthesis of the indolizidine alkaloid skeleton with appropriate functionality and stereochemistry for use as a 'chiral scaffold'

被引：14

作者：

Farrant, E ^{[1
]}

Mann, J ^{[1
]}

机构：

[1] UNIV READING,DEPT CHEM,READING RG6 2AD,BERKS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 08期

关键词：

D O I：

10.1039/a701193h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereocontrolled synthesis of the indolizidine alkaloid skeleton has been achieved via an intramolecular, photo-induced reaction of (SS)-5-triisopropylsilyloxymethyl-3- {2'-[(3''S)-3''-methoxypyrrolidinyl]ethyl}furan-2-(5H)-one, which can be obtained in a highly convergent fashion from (5S)-5-triisopropylsilyloxymethyltetrahydrofuran-2-one and (3S)-3-methoxypyrrolidine.

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页码：1083 / 1084

页数：2

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