Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML

被引：76

作者：

Summers, K. ^{[1
]}

Stevens, J.

Kakkas, I.

Smith, M.

Smith, L. L.

MacDougall, F.

Cavenagh, J.

Bonnet, D.

Young, B. D.

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Ctr Med Oncol, London, England

[2] Guys Hosp, Dept Hematol, London, England

[3] St Bartholomews Hosp, Dept Hematol, London, England

[4] Canc Res UK, London Res Inst, Haematopoiet Stem Cell Lab, London, England

来源：

LEUKEMIA | 2007年 / 21卷 / 03期

关键词：

D O I：

10.1038/sj.leu.2404514

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：550 / 551

页数：2

共 8 条

[1] The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells [J].

Ellisen, LW ;

Carlesso, N ;

Cheng, T ;

Scadden, DT ;

Haber, DA .

EMBO JOURNAL, 2001, 20 (08) :1897-1909

[2] Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias [J].

Fitzgibbon, J ;

Smith, LL ;

Raghavan, M ;

Smith, ML ;

Debernardi, S ;

Skoulakis, S ;

Lillington, D ;

Lister, TA ;

Young, BD .

CANCER RESEARCH, 2005, 65 (20) :9152-9154

[3] Wilms' tumour gene 1 (WT1) in human neoplasia [J].

Keilholz, U ;

Menssen, HD ;

Gaiger, A ;

Menke, A ;

Oji, Y ;

Oka, Y ;

Scheibenbogen, C ;

Stauss, H ;

Thiel, E ;

Sugiyama, H .

LEUKEMIA, 2005, 19 (08) :1318-1323

[4] Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance [J].

King-Underwood, L ;

Pritchard-Jones, K .

BLOOD, 1998, 91 (08) :2961-2968

[5] A novel fluorescence-based multiplex PCR assay for rapid simultaneous detection of CEBPA mutations and NPM mutations in patients with acute myeloid leukemias [J].

Lin, L-I ;

Lin, T-C ;

Chou, W-C ;

Tang, J-L ;

Lin, D-T ;

Tien, H-F .

LEUKEMIA, 2006, 20 (10) :1899-1903

[6] Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics:: are we ready for a prognostically prioritized molecular classification? [J].

Mrozek, Krzysztof ;

Marcucci, Guido ;

Paschka, Peter ;

Whitman, Susan P. ;

Bloomfield, Clara D. .

BLOOD, 2007, 109 (02) :431-448

[7] Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia [J].

Noguera, NI ;

Ammatuna, E ;

Zangrilli, D ;

Lavorgna, S ;

Divona, M ;

Buccisano, F ;

Amadori, S ;

Mecucci, C ;

Falini, B ;

Lo-Coco, F .

LEUKEMIA, 2005, 19 (08) :1479-1482

[8] Wilms' tumor 1 mutation accumulated during therapy in acute myeloid leukemia:: biological and clinical implications [J].

Nyvold, C. G. ;

Stentoft, J. ;

Braendstrup, K. ;

Melsvik, D. ;

Moestrup, S. K. ;

Juhl-Christensen, C. ;

Hasle, H. ;

Hokland, P. .

LEUKEMIA, 2006, 20 (11) :2051-2054

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