The effect of sertindole on QTD and TPTE

被引：29

作者：

Nielsen, J. ^{[1
]}

Andersen, M. P. ^{[2
]}

Graff, C. ^{[2
]}

Kanters, J. K. ^{[3
,4
]}

Hardahl, T. ^{[2
]}

Dybbro, J. ^{[5
]}

Struijk, J. J. ^{[2
]}

Meyer, J. M. ^{[6
]}

Toft, E. ^{[2
]}

机构：

[1] Aarhus Univ Hosp, Unit Psychiat Res, Aalborg Psychiat Hosp, DK-9100 Aalborg, Denmark

[2] Aalborg Univ, Dept Hlth Sci & Technol, Ctr Sensory Motor Interact SMI, Aalborg, Denmark

[3] Gentofte Univ Hosp, Dept Cardiol P, Gentofte, Denmark

[4] Univ Copenhagen, Lab Expt Cardiol, Ctr Cardiac Arrhythmia DARC, Danish Natl Res Fdn, Copenhagen, Denmark

[5] Aarhus Univ Hosp, Dept Psychiat, Psychiat Hosp Risskov, Aarhus, Denmark

[6] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2010年 / 121卷 / 05期

关键词：

QT dispersion; sertindole; Tpeak-Tend; QTc; sudden death; torsade de pointes; DE-POINTES; DISPERSION; SURVEILLANCE; SAFETY; RISK;

D O I：

10.1111/j.1600-0447.2009.01534.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown. Method: Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole. ECG was analysed for Fridericia-corrected QT duration (QTcF), QT dispersion and Tpeak-Tend. Results: From a baseline QTcF of 407 +/- 22 ms, mean QTcF prolongation during sertindole treatment was 20 +/- 23 ms, P < 0.01. No effect on QTc dispersion was found (-1 +/- 11 ms; P = 0.41). No increased duration of the Tpeak-Tend interval from baseline was found (+7 +/- 21 ms; P = 0.05). Conclusion: These findings might be related to the absence of confirmed Torsade de Pointes (TdP) cases related to sertindole exposure, despite sertindole's QTc prolonging effects.

引用

页码：385 / 388

页数：4

共 15 条

[1] Investigating the Role of Ventricular Repolarization Morphology in Surface ECGs for Identifying Patients with a History of Drug-Induced Arrhythmias [J].