Arterial stiffness in chronic kidney disease: causes and consequences

被引：121

作者：

Chue, Colin D. ^{[2
,3
]}

Townend, Jonathan N. ^{[2
,3
]}

Steeds, Richard P. ^{[2
,3
]}

Ferro, Charles J. ^{[1
,2
]}

机构：

[1] Univ Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Hosp, Renal Unit, Dept Nephrol, Birmingham B15 2TH, W Midlands, England

[2] Univ Birmingham, Birmingham, W Midlands, England

[3] Queen Elizabeth Hosp, Dept Cardiol, Birmingham B15 2TH, W Midlands, England

来源：

HEART | 2010年 / 96卷 / 11期

关键词：

STAGE RENAL-DISEASE; SMOOTH-MUSCLE-CELLS; PULSE-WAVE VELOCITY; ISOLATED SYSTOLIC HYPERTENSION; GLYCATION END-PRODUCTS; AGE-RELATED-CHANGES; CARDIOVASCULAR MORTALITY; BLOOD-PRESSURE; ENDOTHELIAL FUNCTION; AORTIC STIFFNESS;

D O I：

10.1136/hrt.2009.184879

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic kidney disease is associated with elevated cardiovascular risk, and heart failure and arrhythmias are the biggest causes of cardiovascular death in this population. Increased arterial stiffness is a hallmark of chronic kidney disease and is associated with adverse alterations in cardiac structure and function that may predispose to an increased risk of cardiovascular death. These changes are already apparent in early kidney disease, which is highly prevalent in the developed world. The mechanisms underlying increased arterial stiffness in chronic kidney disease are undoubtedly complex, but an understanding is paramount to enable the development of novel therapeutic strategies to prevent or reverse this pathophysiology and therefore reduce the cardiovascular disease burden in this high-risk cohort.

引用

页码：817 / 823

页数：7

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