Replicating vesicles as models of primitive cell growth and division

被引:146
作者
Hanczyc, MM
Szostak, JW [1 ]
机构
[1] Massachusetts Gen Hosp, Howard Hughes Med Inst, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
基金
美国国家航空航天局;
关键词
D O I
10.1016/j.cbpa.2004.10.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Primitive cells, lacking the complex bio-machinery present in modern cells, would have had to rely on the self-organizing properties of their components and on interactions with their environment to achieve basic cellular functions such as growth and division. Many bilayer-membrane vesicles, depending on their composition and environment, can exhibit complex morphological changes such as growth, fusion, fission, budding, internal vesicle assembly and vesicle-surface interactions. The rich dynamic properties of these vesicles provide interesting models of how primitive cellular replication might have occurred in response to purely physical and chemical forces.
引用
收藏
页码:660 / 664
页数:5
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