A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron

被引：45

作者：

Gannoun-Zaki, L

Jost, A

Mu, JB

Deitsch, KW

Wellems, TE

机构：

[1] NIAID, LMVR, NIH, Bethesda, MD 20892 USA

[2] Cornell Univ, Weill Med Coll, Dept Immunol & Microbiol, New York, NY USA

来源：

EUKARYOTIC CELL | 2005年 / 4卷 / 02期

关键词：

D O I：

10.1128/EC.4.2.490-492.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Introns of Plasmodium falciparum var genes act as transcriptional silencing elements that help control antigenic variations. In transfected episomes, intron silencing of a drug-selectable marker under var promoter control is reversed by the spontaneous deletion of key intron regions. The resulting promoter activation does not affect the transcription of chromosomal var genes.

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收藏

页码：490 / 492

页数：3

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