Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: Nitration or electron donation?

被引：185

作者：

Pannala, A

Razaq, R

Halliwell, B

Singh, S

Rice-Evans, CA

机构：

[1] United Med & Dent Sch Guys & St Thomas Hosp, Guys Hosp, Int Antioxidant Res Ctr, London SE1 9RT, England

[2] Kings Coll London, Int Antioxidant Res Ctr, Dept Pharm, London SW3 6LX, England

[3] Kings Coll London, Int Antioxidant Res Ctr, Dept Pharmacol, London SW3 6LX, England

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1998年 / 24卷 / 04期

关键词：

flavonoids; peroxynitrite; tyrosine nitration; hydroxycinnamates; free radical;

D O I：

10.1016/S0891-5849(97)00321-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxynitrite is a cytotoxic species generated by the reaction between superoxide and nitric oxide. in this study the ability of hydroxycinnamate antioxidants to decrease peroxynitrite-mediated nitratiun of tyrosine was investigated. The results obtained show that all compounds were able to inhibit nitration of tyrosine. The potency of inhibitory activity was in the order; caffeic acid greater than or equal to chlorogenic acid greater than or equal to ferulic acid > p-coumaric acid > o-coumaric acid > In-coumaric acid. Trolox, which was included in the study for comparative purposes, had an activity between that of ferulic acid and p-coumaric acid. The data obtained suggest that hydroxycinnamates can act by one of two possible mechanisms: preferential nitration for monophenolates and electron donation by catecholates. q 1998 Elsevier Science Inc.

引用

页码：594 / 606

页数：13

共 26 条

[1]

[Anonymous], 2004, INT J FOOD MICROBIOL, DOI DOI 10.1016/j.ijfoodmicro.2004.03.022

[2]

BECKMAN JS, 1994, METHOD ENZYMOL, V233, P229, DOI DOI 10.1016/S0076-6879(94)33026-3

[3] ANTIOXIDANT POTENTIAL OF INTERMEDIATES IN PHENYLPROPANOID METABOLISM IN HIGHER-PLANTS [J].