Detection rates of TT virus DNA in serum of umbilical cord blood, breast milk and saliva
被引:37
作者:
Goto, K
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机构:
Nagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, JapanNagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, Japan
Goto, K
[1
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Sugiyama, K
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机构:Nagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, Japan
Sugiyama, K
Ando, T
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机构:Nagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, Japan
Ando, T
Mizutani, F
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机构:Nagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, Japan
Mizutani, F
Terabe, K
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机构:Nagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, Japan
Terabe, K
Tanaka, K
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机构:Nagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, Japan
Tanaka, K
Nishiyama, M
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机构:Nagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, Japan
Nishiyama, M
Wada, Y
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机构:Nagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, Japan
Wada, Y
机构:
[1] Nagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, Japan
[2] Yonaha Gen Hosp, Dept Gynecol, Kuwana 5110838, Japan
polymerase chain reaction;
pregnant women;
horizontal route of transmission;
D O I:
10.1620/tjem.191.203
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
To date, the routes of mother-to-infant transmission of TT virus (TTV) have not been fully elucidated. The present study examines the detection rates of TTV DNA. in the serum of pregnant Japanese women and in cord blood at the time of delivery, as well as in the saliva and breast milk of mothers one-month postpartum. Primers derived from the well-known translated region N22 (N22 system), as well as the untranslated region (UTR system) were used. The prevalence of TTV DNA in the serum of pregnant women was found to be 11.9% (19/160) using the N22 system and 72.4% (55/76) using the UTR system. No TTV DNA was detected in the cord blood samples (0/160) when the N22 system was used for detection but TTV DNA was detected in 11.8% (7/76) of samples studied with the UTR system. Using the N22 system, TTV DNA was not detected in breast milk, but was detected in saliva. However using the UTR system, TTV DNA was detected in both specimens. These results imply that some babies are vertically infected with TTV via cord blood at the time of delivery or via breast milk or saliva. However, further research is necessary to confirm this hypothesis.