Antibody to β-amyloid protein increases acetylcholine in the hippocampus of 12 month SAMP8 male mice

被引：39

作者：

Farr, SA

Banks, WA

Uezu, K

Sano, A

Gaskin, FS

Morley, JE

机构：

[1] VA Med Ctr, GRECC, St Louis, MO 63109 USA

[2] St Louis Univ, Sch Med, Div Geriatr Med, Dept Internal Med, St Louis, MO 63106 USA

[3] Univ Tokushima, Sch Med, Dept Physiol, Tokushima 7708503, Japan

来源：

LIFE SCIENCES | 2003年 / 73卷 / 05期

关键词：

SAMP8; mouse; amyloid beta protein; microdialysis;

D O I：

10.1016/S0024-3205(03)00322-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Amyloid beta protein (Abeta) is the primary constituent of plaque seen in Alzheimer's disease. Abeta is proposed to play an etiological role in Alzheimer's disease and to be a cause of the decrease in the level of acetylcholine in the hippocampus. The SAMP8 strain of mouse develops age-related increases in Abeta and deficits in learning and memory by 12 months of age. We examined in 12 month old SAMP8 mice the effects of giving antibody to Abeta by septal or intracerebroventricular (ICV) injection on acetylcholine levels in the hippocampus. Antibody to Abeta increased acetylcholine in the hippocampus over 100% after ICV injection and over 200% after septal injection. Injection of rabbit serum, antibody directed towards mouse IgG, or a blocking antibody directed towards human interleukin-1beta were without effect. These results suggest that antagonism of Abeta increases acetylcholine concentrations in the hippocampus, an area important for learning and memory. Published by Elsevier Science Inc.

引用

页码：555 / 562

页数：8

共 40 条

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