HIV Type 1 Molecular Epidemiology among High-Risk Clients Attending the Thai Red Cross Anonymous Clinic in Bangkok, Thailand

被引：32

作者：

Arroyo, Miguel A. ^{[1
]}

Phanuphak, Nittaya ^{[2
]}

Krasaesub, Somporn ^{[1
]}

Sirivichayakul, Sunee ^{[3
]}

Assawadarachai, Vatcharain ^{[1
]}

Poltavee, Kultida ^{[1
]}

Pankam, Tippawan ^{[2
]}

Ananworanich, Jintanat ^{[4
]}

Paris, Robert ^{[1
]}

Tovanabutra, Sodsai ^{[5
]}

Kijak, Gustavo H. ^{[5
]}

McCutchan, Francine E. ^{[5
,6
]}

Phanuphak, Praphan ^{[2
]}

Kim, Jerome H. ^{[7
]}

de Souza, Mark ^{[1
]}

机构：

[1] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand

[2] Thai Red Cross AIDS Res Ctr, Bangkok 10330, Thailand

[3] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand

[4] SEARCH, Bangkok 10330, Thailand

[5] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20850 USA

[6] Bill & Melinda Gates Fdn, Seattle, WA 98102 USA

[7] US Mil HIV Res Program, Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2010年 / 26卷 / 01期

关键词：

INJECTING DRUG-USERS; CIRCULATING RECOMBINANT FORM; CRF01-AE/B RECOMBINANT; ENVELOPE SUBTYPES; INFECTION; CRF15-01B; TRIALS; ASSAY; AIDS;

D O I：

10.1089/aid.2009.0150

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several studies have reported an increasing number of non-CRF01_AE infections in high-risk groups in Thailand suggesting a more complex HIV-1 epidemic. This study assessed the complexity of the HIV epidemic among high-risk clients tested for HIV-1 at the Thai Red Cross Anonymous Clinic (TRCAC) between July 1, 2006 and February 28, 2007. HIV-1 genotypes were determined from plasma of infected subjects (n=401) by the multi-region hybridization assay (MHAbce, v. 2). Univariate and multivariate logistic regression analyses were used to determine risk factors associated with HIV prevalence and non-CRF01_AE infection. The estimated overall HIV prevalence was 14.1%: 25.3% among men who have sex with men (MSM), 18.4% among heterosexual women, and 9.6% among heterosexual men. Among the risk factors found to be associated with HIV prevalence were age (25-29 years), risk behavior (MSM), marital status (not single), education (less than high school), and inconsistent condom use. Overall, non-CRF01_AE strains accounted for 18.9% of the infections: 25.3% among MSM and 14.8% and 20.4% among heterosexual women and men, respectively. Our results indicate a concentrated and genetically complex HIV epidemic among Thai MSM. These findings advocate for targeted intervention and prevention measures among high-risk populations in Thailand.

引用

页码：5 / 12

页数：8

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