Epitope affinity for MHC class I determines helper requirement for CTL priming

被引：79

作者：

Franco, A ^{[1
]}

Tilly, DA

Gramaglia, I

Croft, M

Cipolla, L

Meldal, M

Grey, HM

机构：

[1] La Jolla Inst Allergy & Immunol, Div Immunochem, San Diego, CA 92121 USA

[2] Carlsberg Labs, Dept Chem, DK-2500 Valby, Denmark

来源：

NATURE IMMUNOLOGY | 2000年 / 1卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/77827

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We show here that priming and memory generation of antigen-specific CD8(+) cytotoxic T lymphocytes (CTL) does not require help if the immunogen binds major histocompatibility complex (MHC) class I molecules with high affinity. This conclusion was based on the study of three chemically distinct optimal length CTL epitopes with high affinity for the restriction element K-b. In contrast, when two subdominant epitopes with intermediate MHC binding affinity were studied, either a class II MHC-restricted T helper cell epitope or administration of antibody to CD40 was required to obtain significant CTL priming. Depending on the epitope, one source of help was much more efficient than the other.

引用

页码：145 / 150

页数：6

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