Obesity-associated activation of angiotensin and endothelin in the cardiovascular system

被引：91

作者：

Barton, M

Carmona, R

Ortmann, J

Krieger, JE

Traupe, T

机构：

[1] Univ Zurich Hosp, Dept Internal Med, Med Policlin, CH-8091 Zurich, Switzerland

[2] Univ Sao Paulo, Sch Med, Inst Heart, InCor,Lab Genet & Mol Cardiol, Sao Paulo, Brazil

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2003年 / 35卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

diet; adipocyte; blood pressure; vasoconstriction; angiotensin converting enzyme; kidney; vascular; leptin; resistin; adiponectin;

D O I：

10.1016/S1357-2725(02)00307-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The renin-angiotensin system (RAS) and the endothelin system have been implicated in the pathogenesis of human cardiovascular and renal diseases, and inhibition of the RAS markedly improves morbidity and survival. Obesity in humans is associated with an increased risk for the development of hypertension, atherosclerosis and focal-segmental glomerulosclerosis, however the exact mechanisms underlying these pathologies in obese individuals are not known. This article discusses the clinical importance of obesity and the current evidence for local activation of the renin-angiotensin system and its interactions with the endothelin system in obesity and the cardiovascular pathologies associated with it. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：826 / 837

页数：12

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