Effect of Polygala tenuifolia root on behavioral disorders by lesioning nucleus basalis magnocellularis in rat

被引：33

作者：

Chen, YL

Hsieh, CL

Wu, PHB

Lin, JG

机构：

[1] China Med Univ, Grad Inst Chinese Med Sci, Taichung, Taiwan

[2] China Med Univ, Grad Inst Integrat Chinese & Western Med, Taichung, Taiwan

[3] China Med Univ, Inst Chinese Pharmaceut Sci, Taichung, Taiwan

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 95卷 / 01期

关键词：

Polygala tenuifolia Willd; nucleus basalis magnocellularis; passive avoidance test;

D O I：

10.1016/j.jep.2004.06.015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We investigated whether an aqueous extract of Polygala tenuifolia Willd (PTW) could improve the rats' memory and behavioral disorders produced by lesioning nucleus basalis magnocellularis (NBM) in rats. The animals were divided into four groups for surgery, and following that they were orally administered PTW extract for 7 and 21 days. Each group consisted of eight male Sprague-Dawley rats and were treated as follows: Control: no surgery (n = 8), PBS: 1 M (mol/L) phosphate buffered saline (n = 8), IBO: 0.12 M (n = 8), QUIS: 0.12 M (n = 8). Two 0.5 muL injections were made in the vicinity of the bilateral side of the nucleus basalis magnocellularis (NBM). All rats were tested in the neurological tests and the step-through passive avoidance memory test during pre-surgery, surgery and post-surgery drug treatment. The results suggest that PTW extract has some repairing effects on the memory and behavioral disorders produced by lesioning of the NBM in rats. (C) 2004 Published by Elsevier Ireland Ltd.

引用

页码：47 / 55

页数：9

共 31 条

[1] BEHAVIORAL AND NEUROCHEMICAL CONSEQUENCES OF IBOTENIC ACID LESION IN THE SUBTHALAMIC NUCLEUS OF THE COMMON MARMOSET [J].