Co-localization of N-methyl-D-aspartate receptors and substance P (neurokinin-1) receptors in rat spinal cord

被引：18

作者：

Benoliel, R ^{[1
]}

Tanaka, M ^{[1
]}

Caudle, RM ^{[1
]}

Iadarola, MJ ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Neuronal Gene Express Unit, Pain & Neurosensory Mech Branch, NIH, Bethesda, MD 20892 USA

来源：

NEUROSCIENCE LETTERS | 2000年 / 291卷 / 02期

关键词：

glutamate; pain; Onuf's nucleus; motorneurons; intermediolateral nucleus; sympathetic nervous system; parasympathetic nervous system; receptor co-localization;

D O I：

10.1016/S0304-3940(00)01337-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glutamate, substance P (SP), and their receptors have been implicated in the initiation and maintenance of persistent pain through an interaction at second order spinal cord neurons. Employing well-characterized antibodies to the SP receptor and the N-methyl-D-aspartate receptor (NR1 subunit, splice variant missing exon 22), we demonstrate co localization of these receptors on second order neurons at cervical, thoracic, lumbar, and sacral spinal cord levels. The co-localization was marked in lamina I of the dorsal horn at all levels and in the intermediolateral nucleus of the thoraco-lumbar spinal cord nuclei associated with autonomic function. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：61 / 64

页数：4

共 18 条

[1] NEUROTRANSMITTER RECEPTORS .2. AMPA AND KAINATE RECEPTORS [J].

BETTLER, B ;

MULLE, C .

NEUROPHARMACOLOGY, 1995, 34 (02) :123-139

[2] MORPHOLOGICAL CHARACTERIZATION OF SUBSTANCE-P RECEPTOR-IMMUNOREACTIVE NEURONS IN THE RAT SPINAL-CORD AND TRIGEMINAL NUCLEUS CAUDALIS [J].

BROWN, JL ;

LIU, HT ;

MAGGIO, JE ;

VIGNA, SR ;

MANTYH, PW ;

BASBAUM, AI .

JOURNAL OF COMPARATIVE NEUROLOGY, 1995, 356 (03) :327-344

[3] The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord [J].

Dickenson, AH ;

Chapman, V ;

Green, GM .

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1997, 28 (05) :633-638

[4] ENHANCEMENT OF SPINOTHALAMIC NEURON RESPONSES TO CHEMICAL AND MECHANICAL STIMULI FOLLOWING COMBINED MICRO-IONTOPHORETIC APPLICATION OF N-METHYL-D-ASPARTIC ACID AND SUBSTANCE-P [J].

DOUGHERTY, PM ;

WILLIS, WD .

PAIN, 1991, 47 (01) :85-93

[5] SPLICE VARIANTS OF THE N-METHYL-D-ASPARTATE RECEPTOR NR1 IDENTIFY DOMAINS INVOLVED IN REGULATION BY POLYAMINES AND PROTEIN-KINASE-C [J].

DURAND, GM ;

BENNETT, MVL ;

ZUKIN, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6731-6735

[6] EVIDENCE FOR SPINAL N-METHYL-D-ASPARTATE RECEPTOR INVOLVEMENT IN PROLONGED CHEMICAL NOCICEPTION IN THE RAT [J].

HALEY, JE ;

SULLIVAN, AF ;

DICKENSON, AH .

BRAIN RESEARCH, 1990, 518 (1-2) :218-226

[7] NMDA-receptor regulation of substance P release from primary afferent nociceptors [J].

Liu, HT ;

Mantyh, PW ;

Basbaum, AI .

NATURE, 1997, 386 (6626) :721-724

[8] NOXIOUS STIMULI INDUCE AN N-METHYL-D-ASPARTATE RECEPTOR-DEPENDENT HYPERSENSITIVITY OF THE FLEXION WITHDRAWAL REFLEX TO TOUCH - IMPLICATIONS FOR THE TREATMENT OF MECHANICAL ALLODYNIA [J].

MA, QP ;

WOOLF, CJ .

PAIN, 1995, 61 (03) :383-390

[9]

MCCARSON KE, 1994, J NEUROSCI, V14, P712

[10] STRUCTURE AND FUNCTION OF THE NMDA RECEPTOR-CHANNEL [J].

MORI, H ;

MISHINA, M .

NEUROPHARMACOLOGY, 1995, 34 (10) :1219-1237

← 1 2 →