New fibrinolytic agents: Benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation

被引：26

作者：

De Nanteuil, G

Lila-Ambroise, C

Rupin, A

Vallez, MO

Verbeuren, TJ

机构：

[1] Inst Rech Servier, Div Med Chem D, F-92150 Suresnes, France

[2] Inst Rech Servier, Div Angeiol, F-92150 Suresnes, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(03)00233-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and activity of novel benzothiophene derivatives are described. in the t-Pa-induced fibrin clot lysis assay, several compounds inhibit the formation of the tPa-PAI-1 complex with submicromolar IC50. This class of compounds potentially represents a new generation of antithrombotic-fibrinolytic agents. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1705 / 1708

页数：4

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