PML and the oncogenic nuclear domains in regulating transcriptional repression - Commentary

被引：19

作者：

Li, H ^{[1
]}

Chen, JD ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01655 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(00)00144-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Promyelocytic leukemia protein (PML) is a tumor suppressor involved in the t(15;17) translocation that causes acute promyelocytic leukemia (APL). PML is located at multiple nuclear domains known as PML oncogenic domains (PODs), whose structures are dynamically regulated and disrupted in t(15;17) APL cells. PML is involved in several important cellular processes; however, its exact function is unclear. Recently, a POD-associated protein was found to be transcriptional repressor, suggesting a new role for PODs in regulating transcriptional repression.

引用

页码：641 / 644

页数：4

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