Lipoprotein (a) and apolipoprotein (a) in primary antiphospholipid syndrome

Objective: To investigate whether lipoprotein (a) (Lp(a)) and/or apolipoprotein (a) (apo(a)) may be markers for clinical features of 37 patients with primary antiphospholipid syndrome (PAPS) and to compare with 37 age- and sex-matched controls. Methods: Apo(a) and Lp(a) concentrations were determined by ELISA and immunonephelometry, respectively. Results: Only elevated apo(a) concentrations were significant predictor for cerebrovascular insults (OR=14.399, p=0.005, 95% CI: 2.224-93.230). Conclusion: Considering the fact that PAPS patients with cerebrovascular insults had recurrence of cerebrovascular episodes, measurement of apo(a) concentrations will help in the follow-up of those patients and thus in the prediction of future episodes. This finding should be further investigated in a larger study in order to provide adequate therapeutic intervention. (c) 2007 Published by The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.