Stereochemical studies on phosphopantothenoylcysteine decarboxylase from Escherichia coli

被引：10

作者：

Strauss, E ^{[1
]}

Begley, TP ^{[1
]}

机构：

[1] Cornell Univ, Baker Lab, Dept Chem & Biol Chem, Ithaca, NY 14853 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(02)01018-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phosphopantothenoylcysteine decarboxylase catalyzes the decarboxylation of 4'-phosphopantothenoylcysteine (2) to form 4'-phosphopanthetheine (3), an intermediate in the biosynthesis of Coenzyme A. In this study we investigated the stereochemistry of this reaction. Our results show that the decarboxylation proceeds with retention of stereochemistry, and that the pro-R proton at C-beta of the cysteine moiety of 2 is removed during a reversible oxidation of the thiol to a thioaldehyde intermediate. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：339 / 342

页数：4

共 17 条

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