Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative disease

被引:122
作者
Schwab, C [1 ]
DeMaggio, AJ
Ghoshal, N
Binder, LI
Kuret, J
McGeer, PL
机构
[1] Univ British Columbia, Kinsmen Lab Neurol Res, Vancouver, BC V6T 1W5, Canada
[2] Northwestern Univ, Dept Cell & Moll Biol Cognit Neurol, Chicago, IL USA
[3] Northwestern Univ, Alzheimers Dis Ctr, Chicago, IL USA
[4] Ohio State Univ, Coll Med, Dept Med Biochem, Columbus, OH 43210 USA
关键词
casein kinase 1 delta; Alzheimer's disease; Pick's disease; Parkinson's disease; parkinsonism dementia complex of Guam; pallido-ponto-nigral degeneration; granulovacuolar bodies; neurofibrillary and glial tangles; Lewy bodies; immunocytochemistry;
D O I
10.1016/S0197-4580(00)00110-X
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The distribution of casein kinase 1 delta (Cki delta) was studied by immunohistochemistry and correlated with other pathological hallmarks in Alzheimer's disease (AD), Down syndrome (DS), progressive supranuclear palsy (PSP), parkinsonism dementia complex of Guam (PDC), Pick's disease (PiD), pallido-ponto-ni,oral degeneration (PPND), Parkinson's disease (PD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), and elderly controls. Cki delta was found to be associated generally with granulovacuolar bodies and tau-containing neurofibrillary tangles in AD, DS, PSP, PDC, PPND, and controls, and Pick bodies and ballooned neurons in PiD. It was not associated with tan-containing inclusions in astroglia and oligodendroglia in PPND, PSP, and PDC. It was also not associated with tau-negative Lewy bodies in PD and DLB, Hirano bodies in PDC, Marinesco bodies in PD, AD, and controls and "skein"-like inclusions in anterior motor neurons in ALS. The colocalization of the kinase Cki delta and its apparent substrate tau suggests a function for Cki delta in the abnormal processing of tau. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:503 / 510
页数:8
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