Dehydroepiandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni

被引：35

作者：

Fallon, PG ^{[1
]}

Richardson, EJ ^{[1
]}

Jones, FM ^{[1
]}

Dunne, DW ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 1998年 / 5卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/CDLI.5.2.251-253.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Female mice treated with dehydroepiandrosterone sulfate early during infection were partially protected (P < 0.05-0.005) from Schistosoma mansoni infection. Hormone treatment did not modify parasite-specific cellular or humoral responses. Serum dehydroepiandrosterone sulfate levels and testosterone infection were negatively correlated, r = -0.621 and r = -0.653, respectively, with schistosome worm burden. The partial resistance to schistosome infection in dehydroepiandrosterone sulfate-treated female mice may be due to the known antischistosomular activity of testosterone.

引用

页码：251 / 253

页数：3

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