Expression of Interleukin-1 Receptor-Associated Kinase-1 in Non-Small Cell Lung Carcinoma and Preneoplastic Lesions
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作者:
Behrens, Carmen
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Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA
Behrens, Carmen
[2
]
Feng, Lei
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Univ Texas MD Anderson Canc Ctr, Dept Biostat & Appl Math, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA
Feng, Lei
[3
]
Kadara, Humam
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Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA
Kadara, Humam
[2
]
Kim, Hyun-Jung
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Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA
Kim, Hyun-Jung
[2
]
Lee, J. Jack
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Univ Texas MD Anderson Canc Ctr, Dept Biostat & Appl Math, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA
Lee, J. Jack
[3
]
Mehran, Reza
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Univ Texas MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA
Mehran, Reza
[4
]
Hong, Waun Ki
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Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA
Hong, Waun Ki
[2
]
Lotan, Reuben
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Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA
Lotan, Reuben
[2
]
Wistuba, Ignacio I.
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Univ Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA
Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA
Wistuba, Ignacio I.
[1
,2
]
机构:
[1] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Biostat & Appl Math, Houston, TX 77030 USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA
Purpose: To identify the pattern of interleukin-1 receptor-associated kinase (IRAK-1) protein expression in non-small cell lung carcinoma (NSCLC) and corresponding preneoplastic lesions. Experimental Design: Archived tissue from NSCLC (adenocarcinoma and squamous cell carcinoma; n = 306) and adjacent bronchial epithelial specimens (n = 315) were analyzed for the immunohistochemical expression of IRAK-1, and the findings were correlated with patients' clinicopathologic features. Furthermore, we investigated the correlation between IRAK-1 expression and expression of NF-kappa B and IL-1 alpha in tumor specimens. Results: NSCLC tumors showed significantly higher cytoplasmic and lower nuclear IRAK-1 expression than normal epithelium. Squamous dysplasias had significantly higher cytoplasmic IRAK-1 expression than normal epithelium. In tumors, a significant positive correlation was detected between IRAK-1 expression (nuclear and cytoplasmic; P = 0.011) and IL-1 alpha cytoplasmic expression (P < 0.0001). The correlation between the expression of the markers and patients' clinicopathologic features varied according to tumor histologic type and sex. High IRAK-1 cytoplasmic expression correlated with worse recurrence-free survival in women with NSCLC [hazard ratio (HR), 2.204; P = 0.033], but not in men. In adenocarcinoma, combined low level of expression of nuclear IRAK-1 and NF-kappa B correlated significantly with worse overall (HR, 2.485; P = 0.007) and recurrence-free (HR, 3.058; P = 0.006) survivals in stage I/II patients. Conclusions: IRAK-1 is frequently expressed in NSCLC tissue specimens, and this expression is an early phenomenon in the sequential development of lung cancer. IRAK-1 is a novel inflammation-related marker and a potential target for lung cancer chemopreventive strategies. Clin Cancer Res; 16(1); 34-44. (C) 2010 AACR.
机构:Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Pathol,Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
Boukerche, H
Su, ZZ
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机构:Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Pathol,Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
Su, ZZ
Kang, DC
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机构:Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Pathol,Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
Kang, DC
Fisher, PB
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Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Pathol,Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Pathol,Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
机构:
Johnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USAJohnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USA
Gottipati, Sridevi
Rao, Navin L.
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Johnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USAJohnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USA
Rao, Navin L.
Fung-Leung, Wai-Ping
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Johnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USAJohnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USA
机构:Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Pathol,Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
Boukerche, H
Su, ZZ
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机构:Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Pathol,Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
Su, ZZ
Kang, DC
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机构:Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Pathol,Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
Kang, DC
Fisher, PB
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机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Pathol,Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Pathol,Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
机构:
Johnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USAJohnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USA
Gottipati, Sridevi
Rao, Navin L.
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h-index: 0
机构:
Johnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USAJohnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USA
Rao, Navin L.
Fung-Leung, Wai-Ping
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Johnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USAJohnson & Johnson Pharmaceut Res & Dev LLC, Immunol Team, San Diego, CA 92121 USA