Airway remodeling in asthma: Therapeutic implications of mechanisms

被引：96

作者：

Homer, RJ ^{[1
]}

Elias, JA

机构：

[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

[2] Vet Aff Connecticut Healthcare Syst, Pathol & Lab Med Serv, West Haven, CT USA

[3] Yale Univ, Sch Med, Pulm & Crit Care Med Sect, New Haven, CT USA

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00035.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Asthma is currently recognized as a chronic inflammatory disorder of the airways that leads to tissue injury and subsequent structural changes collectively called airway remodeling. Transgenic modeling of inflammatory mediators allows for the discovery of unexpected effects, dissection of downstream signaling events, and clues to future therapies.

引用

页码：28 / 35

页数：8

共 107 条

[1] Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists [J].

Amrani, Y ;

Panettieri, RA .

THORAX, 1998, 53 (08) :713-716

[2] Cockroach extract antigen increases bronchial airway epithelial permeability [J].

Antony, AB ;

Tepper, RS ;

Mohammed, KA .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 110 (04) :589-595

[3] Imbalance between vascular endothelial growth factor and endostatin levels in induced sputum from asthmatic subjects [J].

Asai, K ;

Kanazawa, H ;

Otani, K ;

Shiraishi, S ;

Hirata, K ;

Yoshikawa, J .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 110 (04) :571-575

[4] Airway wall thickness in patients with near fatal asthma and control groups:: assessment with high resolution computed tomographic scanning [J].

Awadh, N ;

Müller, NL ;

Park, CS ;

Abboud, RT ;

FitzGerald, JM .

THORAX, 1998, 53 (04) :248-253

[5] Airway structural alterations selectively associated with severe asthma [J].

Benayoun, L ;

Druilhe, A ;

Dombret, MC ;

Aubier, M ;

Pretolani, M .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 167 (10) :1360-1368

[6] Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma - Influence of inhaled corticosteroids [J].

Boulet, LP ;

Turcotte, H ;

Laviolette, M ;

Naud, F ;

Bernier, MC ;

Martel, S ;

Chakir, J .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (04) :1308-1313

[7] AIRWAY RESPONSIVENESS AND BRONCHIAL-WALL THICKNESS IN ASTHMA WITH OR WITHOUT FIXED AIR-FLOW OBSTRUCTION [J].

BOULET, LP ;

BELANGER, M ;

CARRIER, G .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (03) :865-871

[8] Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine [J].

Boulet, LP ;

Laviolette, M ;

Turcotte, H ;

Cartier, A ;

Dugas, M ;

Malo, JL ;

Boutet, M .

CHEST, 1997, 112 (01) :45-52

[9] MYOFIBROBLASTS AND SUBEPITHELIAL FIBROSIS IN BRONCHIAL-ASTHMA [J].

BREWSTER, CEP ;

HOWARTH, PH ;

DJUKANOVIC, R ;

WILSON, J ;

HOLGATE, ST ;

ROCHE, WR .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1990, 3 (05) :507-511

[10] Future research directions in asthma - An NHLBI working group report [J].

Busse, W ;

Banks-Schlegel, S ;

Noel, P ;

Ortega, H ;

Taggart, V ;

Elias, L .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 170 (06) :683-690

← 1 2 3 4 5 6 7 8 9 10 →