Demonstration of L-dopa decarboxylating neurons specific to human striatum

被引：48

作者：

Ikemoto, K

Kitahama, K

Jouvet, A

Arai, R

Nishimura, A

Nishi, K

Nagatsu, I

机构：

[1] FUJITA HLTH UNIV,SCH MED,DEPT ANAT,TOYOAKE,AICHI 47011,JAPAN

[2] HOP NEUROL & NEUROCHIRURG P WERTHEIMER,NEUROPATHOL LAB,LYON,FRANCE

[3] SHIGA UNIV MED SCI,DEPT LEGAL MED,OTSU,SHIGA 52021,JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 232卷 / 02期

关键词：

basal ganglia; striatum; nucleus accumbens; aromatic L-amino acid decarboxylase; tyrosine hydroxylase; L-dopa; dopamine; immunohistochemistry;

D O I：

10.1016/S0304-3940(97)00587-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the human striatum, we immunohistochemically demonstrated many neurons that were immunoreactive for aromatic L-amino acid decarboxylase (AADC; the second step dopamine-synthesizing enzyme) but not for tyrosine hydroxylase (TH; the first step dopamine-synthesizing enzyme). The number of AADC-positive neurons was especially large in the ventral striatum including the nucleus accumbens. The significance of AADC-positive neurons are discussed in relation to the acting sites of L-dopa and antipsychotic drugs. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：111 / 114

页数：4

共 20 条

[1] L-DOPA IS CONVERTED TO DOPAMINE IN SEROTONERGIC FIBERS OF THE STRIATUM OF THE RAT - A DOUBLE-LABELING IMMUNOFLUORESCENCE STUDY [J].