Synthesis and application of chiral phospholane ligands bearing a sterically and electrically adjustable moiety

被引：48

作者：

Matsumura, K ^{[1
]}

Shimizu, H ^{[1
]}

Saito, T ^{[1
]}

Kumobayashi, H ^{[1
]}

机构：

[1] Takasago Int Corp, Cent Res Lab, Hiratsuka, Kanagawa 2540073, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2003年 / 345卷 / 1-2期

关键词：

asymmetric catalysis; hydrogenation; ligand design; P-ligands; rhodium;

D O I：

10.1002/adsc.200390008

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of C-1-symmetric phosphine-phospholane ligands, 1-(disubstituted phosphino)-2-(phospholano)benzenes (5), which are called UCAPs, with an achiral phosphino group and a chiral phospholane which can be sterically and electrically adjustable, has been designed and synthesized. In the asymmetric hydrogenation of (Z)-N-benzoyl-1-phenylpropenamine (3), the stereorecognition abilities of the 5d - e-Rh catalysts which have a bulkier aryl substituent on the achiral phosphorus are superior to that observed with the DuPHOS-Rh catalyst. ne effects of varying substituents on the achiral phosphorus atom are discussed.

引用

页码：180 / 184

页数：5

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