T cell fitness determined by signal strength

被引：388

作者：

Gett, AV ^{[1
]}

Sallusto, F ^{[1
]}

Lanzavecchia, A ^{[1
]}

Geginat, J ^{[1
]}

机构：

[1] Inst Res Biomed, CH-6500 Bellinzona, Switzerland

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 04期

关键词：

D O I：

10.1038/ni908

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two potential outcomes confront proliferating antigen-stimulated naive T cells: differentiation to effector and memory cells, or deletion. How stimulation affects cell fate is unclear. Autonomous CD8(+) T cell differentiation has been proposed, but this does not explain the abortive proliferation of T cells induced by immature dendritic cells. Here we show that human and mouse CD4(+) and CD8(+) T cells receiving short or weak stimulation of the T cell receptor proliferate in response to interleukin 2 (IL-2) but are not 'fit' because they die by neglect, fail to proliferate in response to IL-7 and IL-15 and disappear in vivo. Conversely, prolonged or strong stimulation promotes 'fitness' by enhancing survival and cytokine responsiveness. Our results are consistent with the concept that signal strength drives progressive T cell differentiation and the acquisition of fitness.

引用

页码：355 / 360

页数：6

共 54 条

[31] Homeostatic control of lymphocyte survival: potential origins and implications [J].