Functional magnetic resonance Imaging of human absence seizures

被引：192

作者：

Salek-Haddadi, A ^{[1
]}

Lemieux, L

Merschhemke, M

Friston, KJ

Duncan, JS

Fish, DR

机构：

[1] Natl Soc Epilepsy, MRI Unit, Gerrards Cross SL9 0RJ, Bucks, England

[2] UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London, England

[3] UCL, Inst Neurol, Wellcome Dept Imaging Neurosci, London, England

[4] Natl Hosp Neurol & Neurosurg, Dept Clin Neurophysiol, London WC1N 3BG, England

来源：

ANNALS OF NEUROLOGY | 2003年 / 53卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1002/ana.10586

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied a patient with idiopathic generalized epilepsy and frequent absences, using electroencephalogram-correlated functional magnetic resonance imaging. Four prolonged runs of generalized spike-wave discharge occurred during a 35-minute experiment. Time-locked activation was observed bilaterally within the thalami in conjunction with widespread but symmetrical cortical deactivation with a frontal maximum. We demonstrate the reciprocal participation of focal thalamic and widespread cortical networks during human absence seizures and suggest reductions in cortical blood flow, in response to synchronized electroencephalogram activity.

引用

页码：663 / 667

页数：5

共 20 条

[1] A method for removing imaging artifact from continuous EEG recorded during functional MRI [J].

Allen, PJ ;

Josephs, O ;

Turner, R .

NEUROIMAGE, 2000, 12 (02) :230-239

[2]

Avoli M., 1990, GEN EPILEPSY NEUROBI

[3] Cerebral hemodynamic response to generalized spike-wave discharges [J].

Diehl, B ;

Knecht, S ;

Deppe, M ;

Young, C ;

Stodieck, SRG .

EPILEPSIA, 1998, 39 (12) :1284-1289

[4] LOCAL CEREBRAL METABOLIC-RATE FOR GLUCOSE DURING PETIT MAL ABSENCES [J].

ENGEL, J ;

LUBENS, P ;

KUHL, DE ;

PHELPS, ME .

ANNALS OF NEUROLOGY, 1985, 17 (02) :121-128

[5] Movement-related effects in fMRI time-series [J].

Friston, KJ ;

Williams, S ;

Howard, R ;

Frackowiak, RSJ ;

Turner, R .

MAGNETIC RESONANCE IN MEDICINE, 1996, 35 (03) :346-355

[6] Simultaneous EEG and fMRI of the alpha rhythm [J].

Goldman, RI ;

Stern, JM ;

Engel, J ;

Cohen, MS .

NEUROREPORT, 2002, 13 (18) :2487-2492

[7] ELECTRICAL ACTIVITY OF SUBCORTICAL AREAS IN EPILEPSY [J].

HAYNE, RA ;

BELINSON, L ;

GIBBS, FA .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1949, 1 (04) :437-445

[8] What does fMRI tell us about neuronal activity? [J].

Heeger, DJ ;

Ress, D .

NATURE REVIEWS NEUROSCIENCE, 2002, 3 (02) :142-151

[9] Spike-and-wave discharges of absence seizures asa transformation of sleep spindles: the continuing development of a hypothesis [J].

Kostopoulos, GK .

CLINICAL NEUROPHYSIOLOGY, 2000, 111 :S27-S38

[10] Neurophysiological investigation of the basis of the fMRI signal [J].

Logothetis, NK ;

Pauls, J ;

Augath, M ;

Trinath, T ;

Oeltermann, A .

NATURE, 2001, 412 (6843) :150-157

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