Nonisotopic, semiautomated Plasmodium falciparum bioassay for measurement of antimalarial drug levels in serum or plasma

被引：13

作者：

Noedl, H

Teja-Isavadharm, P

Miller, RS

机构：

[1] Univ Vienna, Inst Pathophysiol, Dept Specif Prophylaxis & Trop Med, A-1095 Vienna, Austria

[2] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok, Thailand

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 11期

关键词：

D O I：

10.1128/AAC.48.11.4485-4487.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A simple, nonisotopic, semiautomated bioassay for the measurement of antimalarial drug levels in plasma or serum based on the quantitation of histidine-rich protein II in malaria culture is presented. The assay requires only small sample volumes and was found to be highly sensitive and reproducible. The results closely paralleled those obtained with isotopic bioassays (R = 0.988, P < 0.001) and high-performance liquid chromatography-electrochemical detection (R = 0.978, P < 0.001).

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收藏

页码：4485 / 4487

页数：3

相关论文

共 12 条

[1]

KARBWANG J, 1993, CLIN PHARM ANTIMALAR, P37

[2] Comparison of bioassay and high performance liquid chromatographic assay of artesunate and dihydroartemisinin in plasma [J].

Kotecka, BM ;

Rieckmann, KH ;

Davis, TME ;

Batty, KT ;

Ilett, KF .

ACTA TROPICA, 2003, 87 (03) :371-375

[3] CHLOROQUINE BIOASSAY USING MALARIA MICROCULTURES [J].

KOTECKA, BM ;

RIECKMANN, KH .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1993, 49 (04) :460-464

[4]

LI XH, 1992, TROP MED PARASITOL, V43, P195

[5] DETERMINATION OF THE ANTIMALARIAL ARTEETHER AND ITS DEETHYLATED METABOLITE DIHYDROARTEMISININ IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH REDUCTIVE ELECTROCHEMICAL DETECTION [J].

MELENDEZ, V ;

PEGGINS, JO ;

BREWER, TG ;

THEOHARIDES, AD .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1991, 80 (02) :132-138

[6] Histidine-rich protein II: a novel approach to malaria drug sensitivity testing [J].

Noedl, H ;

Wernsdorfer, WH ;

Miller, RS ;

Wongsrichanalai, C .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) :1658-1664

[7] Malaria drug-sensitivity testing: new assays, new perspectives [J].

Noedl, H ;

Wongsrichanalai, C ;

Wernsdorfer, WH .

TRENDS IN PARASITOLOGY, 2003, 19 (04) :175-181

[8] Plasmodium falciparum-based bioassay for measurement of artemisinin derivatives in plasma or serum [J].

Teja-Isavadharm, P ;

Peggins, JO ;

Brewer, TG ;

White, NJ ;

Webster, HK ;

Kyle, DE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (03) :954-960

[9] Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria [J].

Teja-Isavadharm, P ;

Watt, G ;

Eamsila, C ;

Jongsakul, K ;

Li, QG ;

Keeratithakul, D ;

Sirisopana, N ;

Luesutthiviboon, L ;

Brewer, TG ;

Kyle, DE .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2001, 65 (06) :717-721

[10]

TRAGER W, 1976, SCIENCE, V190, P792