Regulatory T cells in the control of transplantation tolerance and autoimmunity

被引：82

作者：

Jiang, SP ^{[1
]}

Lechler, RI ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Dept Immunol, Fac Med, London, England

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2003年 / 3卷 / 05期

关键词：

antigen-specificity; autoimmune disease; CD4(+)CD25(+) cells; indirect alloresponse; NKT cells; regulatory T cells; T(R)1; T(H)3; transplantation tolerance;

D O I：

10.1034/j.1600-6143.2003.00124.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A role for immunoregulatory T cells in the maintenance of self-tolerance and in transplantation tolerance has long been suggested, but the identification of such cells has not been achieved until recently. With the characterisation of spontaneously occurring CD4(+)CD25(+) and NK1.1(+) T subpopulations of T cells as regulatory cells in rodents and in humans, together with several in vitro generated regulatory T-cell populations, it seems possible that 'customised' regulatory cells possessing antidonor specificity may become therapeutic tools in clinical transplantation tolerance.

引用

页码：516 / 524

页数：9

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