Recent progress in the field of macrolide antibiotics

被引:16
作者
Henninger, TC [1 ]
机构
[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Raritan, NJ 08869 USA
关键词
ABT-773; acylide; antibiotic; azalide; cethromycin; erythromycin; ketolicle; macrolide; telithromycin;
D O I
10.1517/13543776.13.6.787
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
There continues to be a strong interest within the pharmaceutical industry in the use of macrolides as a starting point for the semisynthesis of novel antibacterial agents. The patenting activity in this area has been significant over the last 3 years. Many of the new patents involve ketolide derivatives, which contain a C-3 ketone modification. This is a direct consequence of the excellent activity against erythromycin-resistant organisms displayed by ketolide derivatives such as telithromycin and cethromycin. Other trends in recent macrolide research include modifications to the azalide scaffold of azithromycin and a renewed interest in 16-membered macrolides. These trends are reviewed by examining the new chemical series that have been revealed in the patent literature over the last 3 years.
引用
收藏
页码:787 / 805
页数:19
相关论文
共 131 条
[1]  
ABBANAT D, 2002, 42 ICAAC SAN DIEG US
[2]  
ABBANAT DR, 2001, 41 ICAAC CHIC US
[3]  
ABBOTT LAB, 2001, Patent No. 0140241
[4]  
ABBOTT LAB, 2001, Patent No. 0177134
[5]  
ABBOTT LAB, 2002, Patent No. 02057286
[6]  
ABBOTT LAB, 2000, Patent No. 0069875
[7]  
ABBOTT LAB, 2000, Patent No. 0075156
[8]  
ALIHODZIC S, 2001, 41 ICAAC CHIC US
[9]  
ANDREOTTI D, 2002, Patent No. 0250092
[10]  
Andreotti D., 2002, PCT Int. Appl., Patent No. [WO 0250091A1, 0250091]