Protein kinases: Six degrees of separation?

被引:47
作者
Scheid, MP [1 ]
Woodgett, JR [1 ]
机构
[1] Ontario Canc Inst, Toronto, ON M5G 2M9, Canada
基金
英国医学研究理事会;
关键词
D O I
10.1016/S0960-9822(00)00349-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent evidence for cross-talk between protein kinase a (PKB) and the Raf-l and NF-kappa B signalling pathways has provided new hints to the complex roles that PKB may play in regulating gene transcription and also raised questions about where and when these targets are relevant.
引用
收藏
页码:R191 / R194
页数:4
相关论文
共 19 条
  • [1] Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    Bonni, A
    Brunet, A
    West, AE
    Datta, SR
    Takasu, MA
    Greenberg, ME
    [J]. SCIENCE, 1999, 286 (5443) : 1358 - 1362
  • [2] Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
    Brunet, A
    Bonni, A
    Zigmond, MJ
    Lin, MZ
    Juo, P
    Hu, LS
    Anderson, MJ
    Arden, KC
    Blenis, J
    Greenberg, ME
    [J]. CELL, 1999, 96 (06) : 857 - 868
  • [3] Cellular survival: a play in three Akts
    Datta, SR
    Brunet, A
    Greenberg, ME
    [J]. GENES & DEVELOPMENT, 1999, 13 (22) : 2905 - 2927
  • [4] Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9
    Fujita, E
    Jinbo, A
    Matuzaki, H
    Konishi, H
    Kikkawa, U
    Momoi, T
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 264 (02) : 550 - 555
  • [5] Induction of NF-κB by the Akt PKB kinase
    Kane, LP
    Shapiro, VS
    Stokoe, D
    Weiss, A
    [J]. CURRENT BIOLOGY, 1999, 9 (11) : 601 - 604
  • [6] The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
    Lu, YL
    Lin, YZ
    LaPushin, R
    Cuevas, B
    Fang, XJ
    Yu, SX
    Davies, MA
    Khan, H
    Furui, T
    Mao, ML
    Zinner, R
    Hung, MC
    Steck, P
    Siminovitch, K
    Mills, GB
    [J]. ONCOGENE, 1999, 18 (50) : 7034 - 7045
  • [7] The lipid phosphatase activity of PTEN is critical for its tumor suppressor function
    Myers, MP
    Pass, I
    Batty, IH
    Van der Kaay, J
    Stolarov, JP
    Hemmings, BA
    Wigler, MH
    Downes, CP
    Tonks, NK
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) : 13513 - 13518
  • [8] Ozes ON, 1999, NATURE, V401, P82
  • [9] Activators and target genes of Rel/NF-κB transcription factors
    Pahl, HL
    [J]. ONCOGENE, 1999, 18 (49) : 6853 - 6866
  • [10] Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
    Paradis, S
    Ruvkun, G
    [J]. GENES & DEVELOPMENT, 1998, 12 (16) : 2488 - 2498