Orf186 represents a new member of the Nudix hydrolases, active on adenosine(5′)triphospho(5′)adenosine, ADP-ribose, and NADH

被引:69
作者
O'Handley, SF
Frick, DN
Dunn, CA
Bessman, MJ [1 ]
机构
[1] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, McCollum Pratt Inst, Baltimore, MD 21218 USA
关键词
D O I
10.1074/jbc.273.6.3192
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
orf186, a new member of the Nudix hydrolase family of genes, has been cloned and expressed, and the protein has been purified and identified as an enzyme highly specific for compounds of ADP. Its three major substrates are adenosine(5') triphospho(5') adenosine, ADP-ribose, and NADH, all implicated in a variety of cellular regulatory processes, supporting the notion that the function of the Nudix hydrolases is to monitor the concentrations of reactive nucleoside diphosphate derivatives and to help modulate their accumulation during cellular metabolism.
引用
收藏
页码:3192 / 3197
页数:6
相关论文
共 53 条
  • [1] SOLUTION STRUCTURE OF THE MUTT ENZYME, A NUCLEOSIDE TRIPHOSPHATE PYROPHOSPHOHYDROLASE
    ABEYGUNAWARDANA, C
    WEBER, DJ
    GITTIS, AG
    FRICK, DN
    LIN, J
    MILLER, AF
    BESSMAN, MJ
    MILDVAN, AS
    [J]. BIOCHEMISTRY, 1995, 34 (46) : 14997 - 15005
  • [2] BASIC LOCAL ALIGNMENT SEARCH TOOL
    ALTSCHUL, SF
    GISH, W
    MILLER, W
    MYERS, EW
    LIPMAN, DJ
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) : 403 - 410
  • [3] AMES BN, 1960, J BIOL CHEM, V235, P769
  • [4] Barik S, 1993, Methods Mol Biol, V15, P277, DOI 10.1385/0-89603-244-2:277
  • [5] Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5'''-P-1,P-3-triphosphate hydrolase
    Barnes, LD
    Garrison, PN
    Siprashvili, Z
    Guranowski, A
    Robinson, AK
    Ingram, SW
    Croce, CM
    Ohta, M
    Huebner, F
    [J]. BIOCHEMISTRY, 1996, 35 (36) : 11529 - 11535
  • [6] DIADENOSINE POLYPHOSPHATES - THEIR BIOLOGICAL AND PHARMACOLOGICAL SIGNIFICANCE
    BAXI, MD
    VISHWANATHA, JK
    [J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 1995, 33 (03) : 121 - 128
  • [7] The MutT proteins or ''nudix'' hydrolases, a family of versatile, widely distributed, ''housecleaning'' enzymes
    Bessman, MJ
    Frick, DN
    OHandley, SF
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (41) : 25059 - 25062
  • [8] CHARACTERIZATION OF THE DEFECT IN THE ESCHERICHIA-COLI MUTT1 MUTATOR GENE
    BHATNAGAR, SK
    BULLIONS, LC
    LEW, G
    BESSMAN, MJ
    [J]. JOURNAL OF BACTERIOLOGY, 1990, 172 (05) : 2802 - 2803
  • [9] BHATNAGAR SK, 1991, J BIOL CHEM, V266, P9050
  • [10] BHATNAGAR SK, 1988, J BIOL CHEM, V263, P8953