Development of a novel chiral spiro ligand bearing oxazoline

被引：38

作者：

Kato, T ^{[1
]}

Marubayashi, K ^{[1
]}

Takizawa, S ^{[1
]}

Sasai, H ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Dept Chem, Osaka 5670047, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 23期

关键词：

D O I：

10.1016/j.tetasy.2004.09.037

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of bis(oxazoline) ligand 1 bearing a spiro skeleton is achieved via double ring-closing metathesis (RCM) of tetraene 2 and subsequent oxazoline ring formation using N-bromosuccinimide (NBS). The Cu-spiro bis(oxazoline) complexes prepared from 1 and Cu(OTf)(2) or Cu(OAc)(2) act efficiently as chiral catalysts for promoting carbonyl-ene reactions or Henry reactions with good enantiocontrol. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3693 / 3697

页数：5

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