Risks and benefits of phase 1 clinical trials evaluating new anticancer agents - A case for more innovation

被引:17
作者
Chen, EX
Tannock, IF
机构
[1] Princess Margaret Hosp, Dept Med Oncol & Hematol, Toronto, ON, Canada
[2] Univ Toronto, Toronto, ON, Canada
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2004年 / 292卷 / 17期
关键词
D O I
10.1001/jama.292.17.2150
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:2150 / 2151
页数:2
相关论文
共 11 条
[1]   Ethics of phase 1 oncology studies - Reexamining the arguments and data [J].
Agrawal, M ;
Emanuel, EJ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (08) :1075-1082
[2]   RESPONSES AND TOXIC DEATHS IN PHASE-I CLINICAL-TRIALS [J].
DECOSTER, G ;
STEIN, G ;
HOLDENER, EE .
ANNALS OF ONCOLOGY, 1990, 1 (03) :175-181
[3]  
Dent SF, 1996, ANN ONCOL, V7, P561
[4]   Phase I clinical trial design in cancer drug development [J].
Eisenhauer, EA ;
O'Dwyer, PJ ;
Christian, M ;
Humphrey, JS .
JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (03) :684-692
[5]   THERAPEUTIC RESPONSE AND POTENTIAL PITFALLS IN PHASE-I CLINICAL-TRIALS OF ANTICANCER AGENTS CONDUCTED IN JAPAN [J].
ITOH, K ;
SASAKI, Y ;
MIYATA, Y ;
FUJII, H ;
OHTSU, T ;
WAKITA, H ;
IGARASHI, T ;
ABE, K .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1994, 34 (06) :451-454
[6]   Factors associated with failure to publish large randomized trials presented at an oncology meeting [J].
Krzyzanowska, MK ;
Pintilie, M ;
Tannock, IF .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (04) :495-501
[7]   Perceptions of patients and physicians regarding phase I cancer clinical trials: Implications for physician-patient communication [J].
Meropol, NJ ;
Weinfurt, KP ;
Burnett, CB ;
Balshem, A ;
Benson, AB ;
Castel, L ;
Corbett, S ;
Diefenbach, M ;
Gaskin, D ;
Li, Y ;
Manne, S ;
Marshall, J ;
Rowland, JH ;
Slater, E ;
Sulmasy, DP ;
Van Echo, D ;
Washington, S ;
Schulman, KA .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (13) :2589-2596
[8]   Phase I trial design for solid tumor studies of targeted, non-cytotoxic agents: Theory and practice [J].
Parulekar, WR ;
Eisenhauer, EA .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (13) :990-997
[9]   Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials [J].
Roberts, TG ;
Goulart, BH ;
Squitieri, L ;
Stallings, SC ;
Halpern, EF ;
Chabner, BA ;
Gazelle, GS ;
Finkelstein, SN ;
Clark, JW .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 292 (17) :2130-2140
[10]   Accelerated titration designs for phase I clinical trials in oncology [J].
Simon, R ;
Freidlin, B ;
Rubinstein, L ;
Arbuck, SG ;
Collins, J ;
Christian, MC .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (15) :1138-1147