Synthesis of a novel N-hydroxypyrrolidine using enzyme catalysed asymmetric carbon-carbon bond synthesis

被引：31

作者：

Humphrey, AJ ^{[1
]}

Parsons, SF ^{[1
]}

Smith, MEB ^{[1
]}

Turner, NJ ^{[1
]}

机构：

[1] Univ Edinburgh, Edinburgh Ctr Prot Technol, Dept Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 22期

基金：

英国生物技术与生命科学研究理事会;

关键词：

imino sugars; transketolase; asymmetric carbon-carbon bond synthesis;

D O I：

10.1016/S0040-4039(00)00645-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Hydroxypyrrolidine 5 has been prepared in nine steps starting from;3-O-benzylglyceraldehyde 13. The synthetic route employs Escherichia coli transketolase mediated C-C bond synthesis to establish the absolute stereochemistry and a subsequent ring contraction of a 1,2-oxazine 17 to provide the N-hydroxypyrrolidine nucleus. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4481 / 4485

页数：5

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