Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens

被引：32

作者：

Moutaftsi, Magdalini ^{[1
,2
]}

Tscharke, David C. ^{[3
]}

Vaughan, Kerrie ^{[2
]}

Koelle, David M. ^{[4
]}

Stern, Lawrence ^{[5
]}

Calvo-Calle, Mauricio ^{[5
]}

Ennis, Francis ^{[6
]}

Terajima, Masanori ^{[6
]}

Sutter, Gerd ^{[7
]}

Crotty, Shane ^{[2
]}

Drexler, Ingo ^{[8
]}

Franchini, Genoveffa ^{[9
]}

Yewdell, Jon W. ^{[3
]}

Head, Steven R. ^{[10
]}

Blum, Janice ^{[11
]}

Peters, Bjoern ^{[2
]}

Sette, Alex ^{[2
]}

机构：

[1] Infect Dis Res Inst, Seattle, WA 98104 USA

[2] La Jolla Inst Allergy & Immunol, La Jolla, CA USA

[3] NIAID, Viral Dis Lab, Bethesda, MD 20892 USA

[4] Univ Washington, Dept Med, Seattle, WA USA

[5] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01605 USA

[6] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA

[7] Paul Ehrlich Inst, Dept Virol, Munich, Germany

[8] Tech Univ Munich, Inst Virol, Munich, Germany

[9] NCI, Anim Models & Retroviral Vaccines Sect, Bethesda, MD 20892 USA

[10] Scripps Res Inst, DNA Array Core Facil, La Jolla, CA 92037 USA

[11] Indiana Univ, Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA

来源：

FUTURE MICROBIOLOGY | 2010年 / 5卷 / 02期

关键词：

adaptive immunity; epitopes; immunodominant; protection; vaccinia virus; T-CELL RESPONSES; EXTRACELLULAR ENVELOPED VIRUS; MODIFIED VACCINIA VIRUS; HUMAN DENDRITIC CELLS; IMMUNE EPITOPE DATABASE; TRANSCRIPTION INITIATION; NEUTRALIZING ANTIBODIES; COMPREHENSIVE ANALYSIS; POXVIRUS INFECTION; CROSS-PRESENTATION;

D O I：

10.2217/FMB.09.110

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vaccinia virus (VACV) was used as the vaccine strain to eradicate smallpox. VACV is still administered to healthcare workers or researchers who are at risk of contracting the virus, and to military personnel. Thus, VACV represents a weapon against outbreaks, both natural (e.g., monkeypox) or man-made (bioterror). This virus is also used as a vector for experimental vaccine development (cancer/infectious disease). As a prototypic poxvirus, VACV is a model system for studying host-pathogen interactions. Until recently, little was known about the targets of host immune responses, which was likely owing to VACVs large genome (>200 open reading frames), However, the last few years have witnessed an explosion of data, and VACV has quickly become a useful model to study adaptive immune responses. This review summarizes and highlights key findings based on identification of VACV antigens targeted by the immune system (CD4, CD8 and antibodies) and the complex interplay between responses.

引用

页码：221 / 239

页数：19

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