Hepatoprotective activity of Emblica officinalis and Chyavanaprash

被引：89

作者：

Jose, JK ^{[1
]}

Kuttan, R ^{[1
]}

机构：

[1] Amala Canc Res Ctr, Trichur 680553, Kerala, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 72卷 / 1-2期

关键词：

Chyavanaprash; Emblica officinalis; hepatoprotection; herbal drugs;

D O I：

10.1016/S0378-8741(00)00219-1

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Hepatoprotective activity of Emblica officinalis (EO) and Chyavanaprash (CHY) extracts were studied using carbon tetrachloride (CCl4) induced liver injury model in rats. EO and CHY extracts were found to inhibit the hepatotoxicity produced by acute and chronic CCl4 administration as seen from the decreased levels of serum and liver lipid peroxides (LPO), glutamate-pyruvate transaminase (GPT), and alkaline phosphatase (ALP). Chronic CCl4 administration was also found to produce liver fibrosis as seen from the increased levels of collagen hydroxyproline and pathological analysis. EO and CHY extracts were found to reduce these elevated levels significantly, indicating that the extract could inhibit the induction of fibrosis in rats. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 140

页数：6

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