Attributable mortality of Acinetobacter baumannii:: no longer a controversial issue

被引:148
作者
Falagas, Matthew E. [1 ]
Rafailidis, Petros I.
机构
[1] Alfa Inst Biomed Sci, Athens, Greece
[2] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA
[3] Henry Dunant Hosp, Dept Med, Athens, Greece
关键词
D O I
10.1186/cc5911
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
There has been controversy regarding the mortality directly attributed to Acinetobacter baumannii infections. Data from six case-control studies have been recently added to the literature regarding the attributable mortality of A. baumannii infections during the past months. The information from these studies, added to the previous knowledge on this issue, provides evidence that A. baumannii infections are indeed associated with increased mortality. In addition, there is relevant evidence from studies examining the effect of inappropriate treatment on mortality; specifically, inappropriate treatment of A. baumannii infections has been associated with excess mortality. We believe that the accumulated data suggest that attributable mortality due to A. baumannii infections should no longer be a controversial issue. The efforts of the scientific community interested in this pathogen should therefore be directed to the development and introduction of new antibiotics effective against multidrug-resistant and pandrug-resistant A. baumannii as well as the implementation of infection control measures that may help us in the control of the increasing problem of A. baumannii infections.
引用
收藏
页数:3
相关论文
共 14 条
[1]  
Falagas ME, 2006, CRIT CARE, V10, DOI [10.1186/cc4910, 10.1186/cc4869]
[2]  
Falagas ME, 2006, CLIN INFECT DIS, V43, P389, DOI 10.1086/505599
[3]   Comparison of mortality of patients with Acinetobacter baumannii bacteraemia receiving appropriate and inappropriate empirical therapy [J].
Falagas, Matthew E. ;
Kasiakou, Sofia K. ;
Rafailidis, Petros I. ;
Zouglakis, George ;
Morfou, Panayiota .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 57 (06) :1251-1254
[4]   The epidemiology and control of Acinetobacter baumannii in health care facilities [J].
Fournier, PE ;
Richet, H .
CLINICAL INFECTIOUS DISEASES, 2006, 42 (05) :692-699
[5]   Colonization or infection with multidrug-resistant Acinetobacter baumannii may be an independent risk factor for increased mortality [J].
Gkrania-Klotsas, Effrossyni ;
Hershow, Ronald C. .
CLINICAL INFECTIOUS DISEASES, 2006, 43 (09) :1224-1225
[6]   Attributable mortality of nosocomial Acinetobacter Bacteremia [J].
Grupper, Mordechai ;
Sprecher, Hanna ;
Mashiach, Tania ;
Finkelstein, Renato .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2007, 28 (03) :293-298
[7]   Does antibiotic selection impact patient outcome? [J].
Harbarth, Stephan ;
Nobre, Vandack ;
Pittet, Didier .
CLINICAL INFECTIOUS DISEASES, 2007, 44 (01) :87-93
[8]   Impact of imipenem resistance on mortality in patients with Acinetobacter bacteraemia [J].
Kwon, Ki Tae ;
Oh, Won Sup ;
Song, Jae-Hoon ;
Chang, Hyun-Ha ;
Jung, Sook-In ;
Kim, Shin-Woo ;
Ryu, Seong Yeol ;
He, Sang Taek ;
Jung, Dong Sik ;
Rhee, Ji-Young ;
Shin, Sang Yop ;
Ko, Kwan Soo ;
Peck, Kyong Ran ;
Lee, Nam Yong .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 59 (03) :525-530
[9]   Risk factors of mortality for nosocomial pneumonia: importance of initial anti-microbial therapy [J].
Lee, SC ;
Hua, CC ;
Yu, TJ ;
Shieh, WB ;
See, LC .
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2005, 59 (01) :39-45
[10]   Carbapenem-resistant Acinetobacter baumannii in intensive care unit patients:: risk factors for acquisition, infection and their consequences [J].
Playford, E. G. ;
Craig, J. C. ;
Iredell, J. R. .
JOURNAL OF HOSPITAL INFECTION, 2007, 65 (03) :204-211