Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy

被引：14

作者：

Brockmann, K

Pouwels, PJW

Dechent, P

Flanigan, KM

Frahm, J

Hanefeld, F

机构：

[1] Univ Gottingen, Childrens Hosp, Dept Pediat & Neuropediat, D-37075 Gottingen, Germany

[2] Max Planck Inst Biophys Chem, Biomed NMR Forsch GMBH, D-37077 Gottingen, Germany

[3] Univ Utah, Sch Med, Dept Neurol, Salt Lake City, UT USA

[4] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA

[5] Univ Utah, Sch Med, Dept Human Genet, Salt Lake City, UT 84132 USA

来源：

BRAIN & DEVELOPMENT | 2003年 / 25卷 / 01期

关键词：

magnetic resonance spectroscopy; giant axonal neuropathy; demyelination; leukoencephalopathy;

D O I：

10.1016/S0387-7604(02)00154-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：45 / 50

页数：6

共 21 条

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BERG BO, 1972, PEDIATRICS, V49, P894

[2] N-ACETYL-L-ASPARTIC ACID - A LITERATURE-REVIEW OF A COMPOUND PROMINENT IN H-1-NMR SPECTROSCOPIC STUDIES OF BRAIN [J].